Are you a truck driver or shift worker planning to catch up on some sleep this weekend?

Cramming in extra hours of shut-eye may not make up for those lost pulling all-nighters, new research indicates.

The damage may already be done — brain damage, that is, said neuroscientist Sigrid Veasey from the University of Pennsylvania.

The widely held idea that you can pay back a sizeable “sleep debt” with long naps later on seems to be a myth, she said in a study published this week in the Journal of Neuroscience.

Long-term sleep deprivation saps the brain of power even after days of recovery sleep, Veasey said. And that could be a sign of lasting brain injury.

The discovery that long-term sleep loss can result in a loss of brain cells is a first, Veasey said.

They hope their research will result in medicines that will help people working odd hours cope with the consequences of irregular sleep.

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